What are the symptoms of Krabbe Disease?

Just like most other forms of Leukodystrophy, Krabbe Disease is progressive in nature, and symptoms worsen over the course of the diseases. As myelin breaks down, so does signal transmission in the nervous system resulting in a continuous decline in mental and physical ability.

Symptoms that may accompany Krabbe Disease include:

  • Failure to thrive
  • Hearing loss
  • Vision loss
  • Irritability
  • Change in muscle tone (dystonia/hypertonia)
  • Seizures
  • Loss of speech, slurring
  • Inability to eat by mouth
  • Change in body movements
  • Difficulty breathing
  • Change in walking ability
  • Swallowing difficulty
  • Personality changes

When do symptoms usually start developing?

Early-Infantile Krabbe Disease is the most common type of Krabbe and. In this particular case, symptoms typically present themselves within the first six months of life and the disease progresses rapidly, and usually results in death by the age of two.  See the chart below for additional information on Krabbe Phenotypes:

Phenotypes

Krabbe Disease

  • Symptoms

    What are the symptoms of Krabbe Disease?

  • Causes

    What causes Krabbe Disease?

  • Diagnosis

    How is Krabbe Disease Diagnosed?

  • Treatment

    What are the treatment options?

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Content on this site is not intended to be used as medical advice in the diagnosis or treatment of any condition and is for informational purposes only. Please seek a medical professional if you have questions or health concerns.

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